Peters Endowed Professor of Chemistry
Co-Director, Harvey W. Peters Research Center
E-mail: ncastagn@vt.edu
Office: 401B Davidson Hall
Phone: 540-231-8202
Fax: 540-231-3255
Group Web Pages: http://www.chem.vt.edu/chem-dept/castagnoli/NCIndex.html
Education
1964 Ph.D., Chemistry University of California Berkeley, Calif.
1961 M.S., Endocrinology University of California Berkeley, Calif.
1959 B.S., Chemistry University of California Berkeley, Calif.
Research Interests
Research activities have been devoted primarily to the application of principles of small molecular chemistry to problems in biology, with emphasis on the molecular mechanisms of drug metabolism and pharmacological processes, including neurotoxicity and neuroprotection. A major research interest concerns the molecular mechanisms of monoamine oxidase and cytochrome P-450 catalyzed oxidations and the identification of metabolic pathways that may contribute to the biological properties of the substrate molecules.
Selected Publications
- Castagnoli, N., Jr., Petzer, J., Steyn, Salome, Castagnoli, K., Chen, J-F.,
Schwarzschild, M and Van der Schyf, C. (2003) Monoamine oxidase B inhibition
and neuroprotection: Studies on selective adenosine A2A receptor antagonists.
Neurology, 61 (Supplement 6), S62-S68.
- Bibbiani, F., Oh, J., Petzer, J., Castagnoli, Jr., N., Chen, J-F., Schwarzchild,
M. and Chase, T. (2003) A2A antagonist prevents dopamine agonist-induced motor
complications in animal models of PD. Exp. Neuro., 184,
285-294.
- Beeler, A., Gadepalli, R., Steyn, Salome, Castagnoli, Jr., N. and Rimoldi,
J. (2003) Synthesis and in-vitro biological evaluation of fluoro-substituted-4-phenyl-1,2,3,6-tetrahydropyridines
as monoamine oxidase B substrates. Bioorg. Med. Chem., 11,
5229-5234.
- Bissel, P. and Castagnoli, Jr. , N.(2005) Studies on the cytochrome P450
catalyzed oxidation of 13C labeled 1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine
by 13C NMR. Bioorg. Med. Chem., 13, 2975-2980.
- Frederick, R., Ooms, F., Castagnoli, Jr., N., Petzer, J., Feng, J-F, Schwarzschild,
M., Van der Schyf, C., and Wouter, J. (2005) (E)-8-(3-Chlorostyryl)-1,3,7-trimethylxanthine,
a caffeine derivative acting both as antagonist of adenosine A2A receptors
and as inhibitor of MAO-B. Acta Cryst., C61, o531-o532.
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