Professor, Organic Chemistry
E-mail: gandour@vt.edu
Office: 302 Davidson Hall
Phone: 540-231-3731
Lab Phone: 540-231-7049
Fax: 540-231-3255
Group Web Pages: http://www.chem.vt.edu/chem-dept/gandour/
Research Video Clip http://www.chem.vt.edu/faculty/videos/Gandour.wmv
Education, Honors and Awards
B.S. Wheeling Jesuit College, 1967
Ph.D. Rice University, 1972
Postdoctoral Fellow, University of Kansas, 1971-75
Visiting Research Scientist, Indiana University, 1989-90
Visiting Professor, UCLA, 1990
Fellow, AAAS
Research Interests
Our most recent work focuses on (1) design and synthesis of affordable anti-infectives
and (2) modification of metal oxide surfaces in designing bionano-constructs and
responsive thin films.
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Selected Publications
- Williams, A. A.; Day, B. S.; Kite, B. L.; McPherson, M. K.; Slebodnick,
C.; Morris, J. R.; Gandour, R. D. Homologous, Long-chain Alkyl Dendrons Form
Homologous Thin Films on Silver Oxide Surfaces. Chem. Commun. 2005,
5053-5055. doi:10.1039/b506710c.
- Gandour, R. D. Toward a Design of Affordable, Topical Microbicides: Acylcarnitine
Analogues. Current Pharm. Design 2005, 11,
3757-3767.
- Karlovská, J.; Williams, A. A.; Macri, R. V.; Gandour, R. D.; Funari,
S. S., Uhríková, D.; Balgavy, P. Synchrotron SAX and WAX diffraction
study of a hydrated very long-chain, dendritic amphiphile+DPPC mixture. Coll.
Surf., B. 2007, 54, 160-164. doi:10.1016/j.colsurfb.2006.10.009.
- Williams, A. A.; Sugandhi, E. W.; Macri, R. V.; Falkinham, J. O., III; Gandour,
R. D. Antimicrobial Activity of Long-Chain, Water-Soluble, Dendritic Tricarboxylato
Amphiphiles. J. Antimicrob. Chemother. 2007, 51,
451-458. doi:10.1093/jac/dkl503.
- Sugandhi, E. W.; Macri, R. V.; Williams, A. A.; Kite, B. L.; Slebodnick,
C.; Falkinham, J., III; Esker, A. R.; Gandour, R. D. Synthesis, Critical Micelle
Concentrations, and Antimycobacterial Properties of Homologous, Dendritic
Amphiphiles. Probing Intrinsic Activity and the "Cutoff" Effect. J. Med.
Chem. 2007, 50, 1645-1650. doi:10.1021/jm061240d.
- Sugandhi, E. W.; Falkinham, J. O., III; Gandour, R. D. Synthesis and Antimicrobial
Activity of Symmetrical Two-tailed Dendritic Tricarboxylato Amphiphiles. Bioorg.
Med. Chem. 2007, 15, 3842–3853. doi:10.1016/j.bmc.2007.03.017.
- Sugandhi, E. W.; Slebodnick, C.; Falkinham, J., III; Gandour, R. D. Synthesis
and antimicrobial evaluation of water-soluble, dendritic derivatives of epimeric
5-α-cholestan-3-amines and 5-α-cholestan-3-yl aminoethanoates. Steroids
2007, 72, 615–626. doi:10.1016/j.steroids.2007.04.001
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