Professor Emeritus
E-mail: wolfe@vt.edu
Office: 137 Davidson Hall
Phone: 540-231-8203
Fax: 540-231-3255
Education
B.S. (cum laude) - Chemistry - Lebanon Valley College, 1958
Ph.D. - Chemistry - Indiana University, 1963
Research Interests
Synthesis of New CNS Agents; Synthesis of New Aromatic Polyamides and
Related Polymers; Synthesis of New Antiepileptic Drugs; Mechanistic and
Synthetic Studies of Heteroaromatic SRN1 Reactions; Applications of
Carbanion Chemistry in Organic Synthesis
Selected Publications
- Dandekar, S. A., Greenwood, S. N., Greenwood, T. D., Mabic, S., Merola, J. S., Tanko, J. M., Wolfe, J. F. "Synthesis of Succinimido [3,4-b]indane and 1,2,3,4,5,6-Hexahydro-1,5-methano-3-benzazocine-2,4-dione by Sequential Alkylation of Enolates Derived from N,N,N',N'-Tetramethylbutanediamides and N,N,N',N'-Tetramethylpentanediamides," J. Org. Chem. 1999, 64, in press.
- Wolfe, J. F., Greenwood, T. D., and Mulheron, J. M. "Recent Rends in the Development of New Antiepileptic Drugs," Expert Opinion on Therapeutic Patents, Ashley Publications Ltd. London, 1998, 8, 361.
- Wong, J.-W., Natalie, Jr., K. J., Nwokogu, G., Flaherty, P. T., Greenwood, T. D., and Wolfe, J. F. "The Compatibility of Various Carbanion Nucleophiles with Heteroaromatic Nucleophilic Substitution by the SRN1 Mechanism," J. Org. Chem., 1997, 62, 6152.
- Flaherty, P. T., Greenwood, T. D., Manheim, A. L., Wolfe, J. F. "Synthesis and Evaluation of N-(Phenylacetyl)trifluoromethanesulfonamides as Anticonvulsant Agents," J. Med. Chem., 1996, 39, 1509.
- Campbell, J. A., Greenwood, T. D., Hendi, S. B., Hendi, M. S., Nguyen, P., and Wolfe, J. F. "Reactions of 2-(2-Lithiophenyl)ethyl Chloride with Imines and Isocyanates. Synthesis of 1,2,3,4-Tetrahydroisoquinoline and 3,4-Dihydro-1(2H)-isoquinolinones," Heterocyclic Comm. 1996, 2, 339.
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