University Distinguished Professor
Bioorganic and Natural Products Chemistry
Office: 3111 Hahn Hall South
Group Web Pages: http://www.kingston.chem.vt.edu
BA Cambridge University, 1960
MA Cambridge University, 1963
PhD Cambridge University, 1963
Research Fellow, Queens' College, Cambridge, 1962-66
Research Associate and Fulbright Grantee, Massachusetts Institute of Technology, 1963-64
NATO Fellow, Cambridge University, 1964-66
Assistant Professor of Chemistry, SUNY at Albany, 1966-1971
Associate Professor of Chemistry, Virginia Tech, 1971-1977
Professor of Chemistry, Virginia Tech, 1977-1999
University Distinguished Professor, Virginia Tech, 1999-present
Honors and Awards:
Appointed Research Associate of Missouri Botanical Garden, 1998
Gene Wise Award, Blue Ridge Section, American Chemical Society, April 1999
Research Achievement Award, American Society of Pharmacognosy, July 1999
Virginia Scientist of the Year, 2002
Cook Award for Research, Department of Chemistry, Virginia Tech, May 15, 2004
Virginia Tech Alumni Association Award for Excellence in International Outreach and Research, 2004-2005
Ernest Guenther Award in the Chemistry of Natural Products from the American Chemical Society, 2008
Special birthday issue of the Journal of Natural Products, March 2009
The plants Cordia kingstoniana and Taxus kingstonii named in his honor
Member, National Advisory Council for Complementary and Alternative Medicine, 2010-2014.
Natural products have made a huge contribution to drug discovery and especially to treatment of malaria and cancer. Both artemisinin for treatment of malaria and paclitaxel (Taxol) and its analogs for treatment of cancer are major drugs in their disease areas. Research in our group is focused on the chemistry of biologically active natural products related to cancer and malaria. In the malaria area we are involved in a collaborative search for novel anti-malarial agents from Nature in a collaborative project with Professor Belen Cassera in the Department of Biochemistry. Plant extracts from the former Merck Natural Products Repository are evaluated for antimalarial activity using selective bioassays, and the active constituents are obtained by bioassay-directed fractionation. Structure elucidation is carried out primarily by spectroscopic methods, and in some cases synthetic approaches to the isolated compounds are also employed, in order to confirm structures and to obtain adequate material for biological testing. The mallatojaponins and the kniphofiones are examples of compounds isolated in this work.
The cancer-related project involves improved methods of delivery of the drugs paclitaxel and doxorubicin to tumors using gold nanoparticles linked with the tumor-targeting protein TNF. This project is in collaboration with CytImmune Sciences Inc.
- Eaton, A. L.; Rakotondraibe, L. H.; Brodie, P. J.; Goetz, M.; Kingston, D. G. I. Antiproliferative Trihydroxyalkylcyclohexenones from Pleiogynium timoriense. J. Nat. Prod. 2015, 78, 1752-1755. http://pubs.acs.org/articlesonrequest/AOR-Rv4CwypJ2BMaja3xH7ka;
- Rasamison, V. E.; Rakotondraibe, L. H.; Slebodnick, C.; Brodie, P. J.; Ratsimbason, M.; TenDyke, K.; Shen, Y.; Randrianjanaka, L. M.; Kingston, D. G. I. Nitrogen - Containing Dimeric nor-Multiflorane Triterpene from a Turraea sp. Org. Lett. 2014, 16, 2626-2629. http://pubs.acs.org/doi/full/10.1021/ol500775r.
- Chen, Q.-H., Kingston, D. G. I. Zampanolide and Dactylolide: Cytotoxic Tubulin Assembly Agents and Promising Anticancer Leads. Nat. Prod. Rep. 2014, 31, 1202-1226. DOI: 10.1039/c4np00024b.
- Kingston, D. G. I.; Snyder, J. P. The Quest for a Simple Bioactive Analog of Paclitaxel as a Potential Anticancer Agent. Acc. Chem. Res. 2014, 47, 2682–2691. http://pubs.acs.org/doi/full/10.1021/ar500203h.
- Harinantenaina, L.; Bowman, J. D.; Brodie, P. J.; Slebodnick, C.; Callmander, M. W. Rakotobe, E.; Randrianaivo, R.; Rasamison, V. E. Gorka, A.; Roepe, P. D.; Cassera, M. B.; Kingston, D. G. I. Antiproliferative and antiplasmodial dimeric phloroglucinols from Mallotus oppositifolius from the Madagascar Dry Forest. J. Nat. Prod., 2013, 76, 388-393. http://pubs.acs.org/doi/full/10.1021/np300750q.
- Kingston, D. G. I. Modern Natural Products Drug Discovery and its Relevance to Biodiversity Conservation. J. Nat. Prod. 2011, 74, 496-511. http://pubs.acs.org/doi/full/10.1021/np100550t
- Kingston, D. G. I. Tubulin-Interactive Natural Products as Anticancer Agents. J. Nat. Prod. 2009, 72, 507-515. http://pubs.acs.org/doi/full/10.1021/np800568j
- Kingston, D. G. I. A Natural Love of Natural products. J. Org. Chem. 2008, 73, 3975-3984. http://pubs.acs.org/doi/pdf/10.1021/jo800239a